Dominic Rowe was appointed to the Faculty of Medicine, Human and Health Sciences at Macquarie University in 2007, aged 42, becoming the youngest Professor of Neurology in Australia. He helped establish the Macquarie University health precinct, MQ Health and the Neurology Clinic. He has cared for thousands of people with MND, Parkinson's disease and other neurological conditions. Macquarie's Neurology service cares for more than 250 people with MND and more than 800 with Parkinson's disease.

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Rowe has published more than 140 peer-reviewed manuscripts, written textbook chapters on MND and edited a textbook on the Non-Motor Manifestations of Parkinson's Disease (Oxford University Press). He has more than 6,300 citations, including more than 3,300 in the last five years. His MND research has appeared in Nature Genetics (2016), Nature Communications (2017) and Science Translational Medicine (2018).

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Rowe holds two patents in Parkinson's disease and one in MND and other neurodegenerative diseases.